Taken from the latest EPA report (you can read it all if you wish here:
http://www.epa.govtrilawsandregsntp_chemicalsNTPchemicals_proposed Rule04062010.pdf)
(skipped ahead to relevant subject matter...
9. Nitromethane (CAS No. 75–52–5) (Refs. NTP Profile/Background document (Refs. 25 and 26)).
The National Toxicology Program has classified nitromethane as ‘‘reasonably anticipated to be a human carcinogen.’’ The classification is based on sufficient
evidence of carcinogenicity in experimental animals. The NTP substance profile for nitromethane (Ref. 25) included the following summary information of the evidence of
carcinogenicity:
VerDate Nov<24>2008 16:32 Apr 05, 2010 Jkt 220001 PO 00000 Frm 00026 Fmt 4702 Sfmt 4702 E:\FR\FM\06APP1.SGM 06APP1 sroberts on DSKD5P82C1PROD with PROPOSALS 17342 Federal Register / Vol. 75, No. 65 / Tuesday, April 6, 2010 / Proposed Rules
‘‘Carcinogenicity
Nitromethane is reasonably anticipated to be a human carcinogen based on sufficient evidence of
carcinogenicity in experimental animals. When administered by inhalation, nitromethane significantly
increased the combined incidences of benign and malignant tumors at three tissue sites in mice and at a different tissue site in rats. In mice, nitromethane
caused harderian gland and lung tumors in both sexes and liver tumors in females. In rats, nitromethane caused
mammary gland tumors in female F344/ N rats but did not cause any increased tumors in Long-Evans rats (exposed to
lower levels) (NTP 1997). The International Agency for Research on Cancer (2000) also has concluded that
there was sufficient evidence for the carcinogenicity of nitromethane in experimental animals.
No studies evaluating the carcinogenicity of nitromethane in humans were found in the published literature.
Additional Information Relevant to Carcinogenicity
The mechanism by which nitromethane causes cancer is not known. Nitromethane did not cause mutations in bacteria and does not appear to cause genetic damage in
mammalian test systems. In cultured mammalian cells, nitromethane did not cause chromosomal aberrations
(changes in chromosome structure or number), sister chromatid exchange, or micronucleus formation (a sign of
chromosome damage or loss). Inhalation exposure of mice to nitromethane did not cause micronucleus formation in the erythrocytes (red blood cells), in either bone marrow or peripheral (circulating) blood (IARC 2000). In cultured Syrian hamster embryo cells, nitromethane induced cell transformation (a step in tumor formation) (Kerckaert et al. 1996, NTP 2002).
Nitromethane appears to be absorbed by inhalation; the available data suggest that dermal absorption is negligible.
Metabolism of nitromethane by experimental animals in vivo has not been characterized. Metabolism of
nitromethane by liver microsomes from Fischer 344 rats resulted in formation of only trace amounts of formaldehyde (IARC 2000).’’ EPA has reviewed the NTP cancer assessment for nitromethane and agrees
that nitromethane can reasonably be anticipated to cause cancer in humans. EPA believes that the evidence is
sufficient for listing nitromethane on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the
available carcinogenicity data for this chemical.
NON-expert conclusions;
In short if you are a gerbil or rat you should not inhale Nitromethane! Unless you are of certain varieties of rat. But you can take a bath in it.
Obviously it could the opinion from the data presented that it is why Don Garlits has lasted so long. It can only be assumed he is immune to it being a swamp rat and all.
As well it does not address the burning of it which is known to have euphoric and beneficial nasal clearing effects as well as sensory overload capabilities.
Note: if arrousal persists and should last for more than 4 hours seek immediate treatment in the arms or cleavage of Linda Vaughn or the like!